Sport, your best ally against the biological clock
A recent study has shown that cardiorespiratory fitness is negatively correlated with the acceleration of epigenetic age, even after adjustment for confounding factors. Maintaining good physical condition, combined with optimal body composition, adequate nutrition and a good morning chronotype, is linked to a slowing of biological ageing in older men.
- Biological versus chronological age Biological age reflects your body's actual state of health, unlike chronological age, which is simply based on your date of birth.
- Epigenetic clocks Scientists use DNA methylation markers to accurately measure biological age.
- Physical fitness as a geroprotector Regular exercise acts as a powerful protector against cell ageing.
- Strength and muscle mass: : Muscle mass and strength are crucial for longevity
- Fitness components Physical fitness encompasses cardio-respiratory endurance, muscular strength, flexibility, balance and body composition.
- Waseda study This research has shown a significant correlation between better cardiorespiratory fitness and a younger biological age.
- Cardiorespiratory capacity threshold The study identified a threshold of 22.7 mL/kg/min above which the slowing of biological ageing was significant.
- Body composition Excessive accumulation of visceral fat accelerates cellular ageing, while good calf muscle is associated with a younger biological age.
- Balanced diet An adequate intake of carbohydrates and micronutrients is linked to a slowdown in cell ageing.
- The importance of sleep A morning chronotype (being in the morning) and good quality sleep are associated with a younger biological age.
- Impact of bad habits Smoking and excessive alcohol consumption are powerful accelerators of biological ageing.
What is biological age and why should you care?
Biological age is an indicator that reflects your body's true state of health, beyond the mere passing of years. Unlike your chronological age, it can be influenced by your lifestyle and habits.
Imagine two 50-year-olds: one looks fit, dynamic and full of energy, while the other looks tired, less alert and older. This difference is the perfect illustration of thebiological age in action.
It's not just a question of appearance, but of the real state of your cells and organs.
How is biological age measured?
This is where the epigenetic clocks based on DNA methylation. (Don't worry, we'll get to the bottom of this jargon together!) These clocks are like molecular detectives examining the chemical changes in your DNA over time.
DNA methylation is a bit like your genes wearing little chemical hats that influence their activity. The older you get, the more certain methylation patterns change in a predictable way. Scientists have succeeded in creating algorithms capable of reading these patterns and deducing your biological age.
Why is biological age important?
You may be wondering: "That's all well and good, but what is it actually good for? Imagine that your Your biological age is an excellent indicator of your overall health. It can give you valuable clues about your risk of developing certain age-related diseases, or even about your life expectancy.
It's a bit like getting a glimpse of your body's future state of health. Here's what biological age allows you to do. If your biological age is lower than your chronological age, that's good news! You're on the right track. On the other hand, if it's the opposite, it may be time to review some of your habits. (Don't panic, we'll see later how fitness can help you! And above all, it's never too late!)
The advantage of this indicator is that it is editable.
Unlike your date of birth, which will remain fixed unless you use a time machine, your biological age can be influenced by your lifestyle choices. This is excellent news, because it means that you have the power to influence your long-term health.
How can physical fitness act as a shield against ageing?
Fitness is a veritable elixir of youth for your body. It acts as a "geroprotector", In other words, it protects your cells from the damaging effects of the passage of time.
Decoding physical fitness: much more than just a sculpted body
When we talk about physical fitnessFitness isn't just about having rock-hard abs or being able to run a marathon. It's a much broader and fascinating concept. Think of your body as a complex machine: fitness is your ability to function optimally in different situations.
It is made up of several key elements:
- Cardiorespiratory endurance (your heart and lungs working as a team)
- Muscular strength (the muscles that support you every day)
- Flexibility (your ability to bend over backwards... or almost)
- The balance (your hidden talent to avoid stumbling)
- Body composition (the ratio of your muscles to your body fat)
Each of these aspects plays a vital role in your overall health.
What is geroprotection?
Behind this term, worthy of a science fiction film, lies a fairly simple concept. The geroprotectionIt's everything that protects your body from the effects of ageing. And guess what? Physical exercise is one of the most powerful geroprotectors at your disposal!
When you exercise regularly, you don't just burn calories. You trigger a cascade of biological reactions that literally slow down the ageing of your cells. It's as if you were giving a boost to your "epigenetic clocks" that we were talking about earlier.
The difference between physical activity and physical fitness
You may be thinking: "But I'm active, I move around a lot during the day, that's enough, isn't it?" Well, not quite. There's a subtle but important difference between physical activity and physical fitness.
Physical activity is anything you do that gets you moving: walking to the office, gardening, playing with your children... It's great, don't get me wrong! But physical fitness is the result of regular, planned exercise. It's a bit like the difference between snacking on fruit throughout the day (physical activity) and eating a proper balanced meal (structured exercise).
Research shows that it's your level of physical fitness, in particular your cardiorespiratory capacity and your level of muscle and strength, that has the greatest impact on your long-term health and your biological age. So, if you really want to take advantage of these geroprotective effects, you need to step up a gear and structure your activity a little.
Don't worry, it doesn't mean you have to become an Olympic athlete overnight. Even small changes can make a big difference. The important thing is consistency and progress.
Why are muscle mass and strength crucial to longevity?
1. Preserving muscle mass and ageing
With age, the phenomenon of sarcopenia, which refers to the progressive loss of muscle mass and strength, is inevitable. This decline begins in our thirties and accelerates with each passing decade. The loss of muscle mass not only reduces mobility and independence, but also increases the risk of falls and fractures, critical factors in morbidity among the elderly.
2. Impact on metabolism
Muscles are major consumers of energy and play a key role in regulating basal metabolism. The greater the muscle mass, the more calories the body is able to burn, even at rest. This relationship is essential for preventing obesity and metabolic diseases such as type 2 diabetes. Good muscle mass also improves insulin sensitivity, which in turn promotes better glycaemic control.
3. Reducing the risk of chronic diseases
Studies show that people with greater muscle mass and physical strength have a reduced risk of developing chronic diseases such as cardiovascular disease, hypertension and certain cancers. Skeletal muscle plays an active role in secreting myokines, molecules with anti-inflammatory properties, thus helping to reduce chronic systemic inflammation, a key factor in the development of age-related diseases.
4. Improved bone health
Maintaining muscle mass through regular physical activity and resistance training has a direct effect on bone density. Mechanical stimulation of the bones through muscular effort helps prevent osteoporosis and reduces the risk of fractures. By strengthening both muscles and bones, we promote healthier ageing.
5. Maintaining independence and quality of life
Lastly, having sufficient muscular strength helps maintain functional autonomy, i.e. the ability to carry out daily tasks without outside help, even as we age. This includes activities as simple as walking, climbing stairs, carrying objects or getting up from a chair. People who are able to maintain their strength and muscle mass generally age with greater independence and a better quality of life.
What does the Waseda study tell us about the link between physical fitness and biological age?
The Waseda study reveals a clear correlation between good cardiorespiratory fitness and a younger biological age. It underlines the importance of maintaining adequate physical fitness to slow cellular ageing.
A study on the scientific fountain of youth
You may be wondering: "What's this famous Waseda study all about? To find out, we're going to take a trip to Japan, home of centenarians and the concept of "ikigai" (reason for being). Researchers at Waseda University have conducted a fascinating study, published in 2023.
The aim? Understand how our physical condition and lifestyle habits influence our biological age. In other words, they wanted to find out whether being in shape could really save us a few years of cellular youth.
The method
For this study, the researchers recruited 144 men aged 65 and over. (Yes, only men, which is a limitation of the study, but we'll come back to that later). These gentlemen were subjected to a battery of tests worthy of a presidential check-up:
- Anthropometric measurements (height, weight, waist circumference... in short, they were examined from every angle)
- Blood tests (to check cholesterol and sugar levels, etc.).
- Evaluating their diet (No cheating on granny's dishes!)
- Questionnaires on their lifestyle habits (tobacco, alcohol, sleep)
- And finally a cardiorespiratory condition
Of course, the researchers also took DNA samples to measure the biological age of our volunteer guinea pigs using the famous epigenetic clocks we mentioned earlier.
The results: when cardio rejuvenates your cells
Here's what the study found:
- Men with a better cardiorespiratory condition tended to have a younger biological age. It was as if their physical fitness had slowed down their biological clock!
- There was even a sort of "magic threshold": participants who had a cardiorespiratory capacity greater than 22.7 mL/kg/min (don't worry about the units, just remember that this is a good score for their age) showed a significant slowdown in their biological ageing.
- The study also showed that other factors such as good body composition, a balanced diet and an early morning chronotype (being a morning person) were associated with a younger biological age.
These results are really encouraging. They suggest that taking care of your physical fitness, in particular your heart and lungs, could really help you stay young... at the cellular level anyway!
What other aspects of your lifestyle can influence your biological age?
Your biological age is influenced by many factors beyond physical fitness. Body composition, diet, sleep and habits such as smoking and alcohol consumption all play a crucial role.
Body composition: not just a question of aesthetics
You may think that your waistline is just a matter of loosening a belt? Think again! The Waseda study revealed that the body composition has a significant impact on your biological age. In particular, an excessive accumulation of visceral fat (that sneaky fat that settles around your organs) appears to accelerate cell ageing.
But don't be discouraged if you're a few kilos overweight. The study also showed that a good calf size was associated with a younger biological age. So having the legs of a footballer could well be your ticket to the fountain of youth!
Sleep: your nocturnal ally against ageing
Are you an early bird, an early riser or a night owl? Your chronotype (your natural sleep rhythm) could well influence your biological age. The study showed that early risers tended to have a younger biological age.
But don't worry if you're an incorrigible night owl. The most important thing is to respect your natural rhythm and look after the quality of your sleep. A good night's sleep is a veritable elixir of youth for your cells.
Bad habits: what not to do to stay young
You probably suspected it, but the study confirms it: the smoking and a excessive alcohol consumption are veritable accelerators of biological ageing. These habits have been shown to be strongly correlated with an older biological age.
If you smoke or if you tend to lift your elbow a little too much, now might be the time to think about taking a step back. Your body will thank you, and not just in appearance!
The limitations of the study and our opinion on the future of metabolic age
The future looks bright, with prospects for in-depth research into the link between physical fitness and biological ageing. These studies could revolutionise our approach to personalised health and 'ageing well'.
As you can see, maintaining a good level of physical fitness is not just a question of aesthetics or sporting performance. It's about a real investment in your long-term health. The Waseda study showed us that the physical fitnessYour body's ability to adapt, particularly your cardiorespiratory capacity, can act as a brake on biological ageing. It's as if you had a super-power to slow down time... at the cellular level at least!
But make no mistake, this is only the beginning of the story, as researchers still have their work cut out for them. And why is that? Because the Waseda study, as interesting as it is, is only a snapshot. It shows a correlation, but not necessarily a causation. (Yes, I know, it's all very scientific, but stay with us!)
What we need now, are longitudinal studies:
Imagine following a group of people over 10, 20 or even 30 years, observing how their level of fitness influences their biological age over time. Now that would be something! And what about intervention studies? We could see in real time how a training programme affects biological age. Fascinating, isn't it?
But wait, there's more! The future could well hold even more surprises. Imagine a world where you could know your biological age as easily as you take your temperature. Visit biomarkers of ageinglike the epigenetic clocks we have been talking about, could become commonplace tools for personalised health.
You could monitor in real time the impact of your lifestyle choices on your cellular ageing. Too much stress at work? Your biological clock will tell you. Need to move around a bit more? Your biomarkers will sound the alarm. It's like having your own personal health coach, but at a molecular level!
Of course, all this raises ethical and practical questions. How can this information be used responsibly? How can we make it accessible to everyone? These are the exciting challenges that lie ahead. But one thing is certain: the future of health and wellbeing may well lie in a better understanding of our biological age.
What if you could give your young cells a boost?
NMN (Nicotinamide Mononucleotide) could well be the key to slowing down your biological clock. This direct precursor of NAD+ helps to keep your cells in top shape, even as you age.
The Waseda study showed us the importance of maintaining good physical condition in order to stay biologically 'young'. Well, imagine being able to give your efforts an extra boost! That's where our High-quality NMN comes into play.
Certified 99.9% pure, our NMN is like a super-fuel for your cells. It stimulates the production of NAD+, an essential molecule which, remember, naturally decreases with age. (We're talking about a drop of 50% after 30 years, ouch!)
But what does it actually mean for you? Better stamina, more radiant skin, and a renewed energy that will remind you of your best years. It's like giving your cells a little rejuvenation!
And don't worry, you don't have to eat 100 kg of broccoli a day to benefit. That's what our NMN supplement is for!
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