{"id":19450,"date":"2025-01-03T08:26:15","date_gmt":"2025-01-03T08:26:15","guid":{"rendered":"https:\/\/dixsupps-v2.local\/the-risks-of-taking-nad-nmn\/"},"modified":"2026-02-02T16:59:38","modified_gmt":"2026-02-02T16:59:38","slug":"nmn-nad-danger-secondary-effects-risks","status":"publish","type":"post","link":"https:\/\/dixsupps.com\/en\/nmn-nad-danger-secondary-effects-risks\/","title":{"rendered":"The risks of taking NAD (NMN)"},"content":{"rendered":"

Nicotinamide mononucleotide (NMN) is generating a lot of buzz in the field of longevity and wellness. But what about its safety? With a surge in sales and sometimes exaggerated promises, it is crucial to understand the potential side effects of this dietary supplement.<\/p>\n

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What is NAD\u207a<\/h2>\n

NAD\u207a (nicotinamide adenine dinucleotide)<\/strong> is an essential coenzyme present in all our cells. It is involved in energy production, DNA repair, metabolism regulation, and maintaining proper cellular function.
\nAs we age, NAD\u207a levels naturally tend to decrease, which could contribute to certain signs of aging and a decline in metabolic performance.<\/p>\n

NMN (nicotinamide mononucleotide)<\/strong> is one of the natural precursors of NAD\u207a. It is produced by the body and found in very small amounts in certain foods like avocado, broccoli, cabbage, or tomato.<\/p>\n

A significant amount of these foods would need to be consumed to obtain even a few milligrams of NMN.<\/p><\/blockquote>\n

This is why supplementation with NAD\u207a precursors has become popular in recent years<\/strong>. NMN, for example, is often offered in capsule or powder form, with dosages generally ranging from 50 to 500 mg per intake.<\/p>\n

Research suggests that increasing NAD\u207a levels could have beneficial effects on mitochondrial function, insulin sensitivity, and certain aging markers. However, human clinical data remains limited, and long-term effects require further studies.
\nFor now, short-term trials indicate good tolerance, with no major adverse effects observed at commonly used doses.<\/p>\n

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\r\n \r\n How your NAD+ levels decrease with age<\/span>\r\n Hover over the chart to understand the evolution of your cellular levels<\/span>\r\n\r\n \r\n Natural NAD+<\/span>\r\n NAD+ Supplementation<\/span>\r\n\r\n \r\n Age<\/span>\r\n NAD Level<\/span>\r\n\r\n \r\n 20-30 years<\/span>\r\n Optimal levels<\/span>\r\n NAD+ is at its peak. Mitochondria operate at full capacity, DNA repair is efficient, and energy metabolism is optimal. Supplementation does not provide significant benefit at this age.<\/span>\r\n\r\n \r\n 30-45 years<\/span>\r\n Beginning of decline<\/span>\r\n NAD+ levels start to gradually decrease. NAD+-consuming enzymes (CD38, PARP) become more active with age. NMN supplementation can begin to slow this loss.<\/span>\r\n\r\n \r\n 45-60 years<\/span>\r\n Critical threshold<\/span>\r\n The decline accelerates. At 60 years, levels represent only 50% of those of a young adult. Mitochondrial function decreases, insulin sensitivity degrades, and signs of aging become more pronounced. This is the period where supplementation shows the most difference.<\/span>\r\n\r\n \r\n 60-70 years<\/span>\r\n Advanced decline<\/span>\r\n NAD+ levels are very low. The gap between a supplemented and non-supplemented person reaches about 25%. Supplementation allows maintaining levels comparable to those of a 40-45-year-old non-supplemented person.<\/span>\r\n\r\n \r\n 50% NAD+ level at 60 years<\/span>\r\n 25% difference<\/span>\r\n\r\n \r\n Your NAD+ levels at 60 years represent only 50% of your optimal young adult levels (20 years)<\/span>\r\n Supplementation delays the 50% NAD+ loss by 25-30 years<\/span>\r\n\r\n<\/div>\r\n\r\n\r\n

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Scientific research on NAD\u207a and its precursors<\/h2>\n

In recent years, several studies have focused on NAD\u207a and its precursors such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside).<\/p>\n

Research is generally reassuring<\/strong>. A systematic review published in 2024, involving more than 400 participants, concluded that supplementation with NAD\u207a precursors was well tolerated<\/strong> and no serious adverse effects were observed, even at doses ranging from 250 to 1000 mg per day.<\/p>\n

Among the most notable studies:<\/p>\n