ZMA
3 forms of Zinc Magnesium High Bioavailability
✓ 3 Forms of magnesium
✓ 3 Forms of zinc
✓ Chelated form
✓ No digestive problems
✓ No additives
✓ Vitamin B6
✓ Made in France
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20,00 €
Made in France
Superior quality
High Absorption
No Additives
Product often consumed with our ZMA
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Contents
WHY TAKE THE ZMA DIX?
The use of three forms of zinc and magnesium not only gives you the benefits of three sources with optimal benefits, but also enables you to use several absorption channels, optimising bioavailability and therefore the benefits of the minerals.
The choice of high-quality ingredients such as chelated magnesium bisglycinate also ensures enhanced quality and benefits.
The result is a complex with an optimised, high-quality and unique formula. A true 10/10
WHY IS MAGNESIUM IMPORTANT?
Magnesium is an essential dietary nutrient and one of the most abundant minerals in the body. Magnesium acts as an electrolyte and is a cofactor for more than 600 enzymes.
Magnesium is required for energy production (ATP), glucose metabolism, DNA and protein synthesis, nerve conduction, bone health and cardiovascular regulation, among other functions. It also plays a crucial role in the synthesis and activation of vitamin D.
More than half of adults may not meet the recommended daily intake of magnesium. This is due to the consumption of processed foods. Magnesium deficiency (which increases the risk of obesity, diabetes, cardiovascular disease, metabolic syndrome and osteoporosis) is therefore a major public health problem.
WHY IS ZINC IMPORTANT?
Zinc is a mineral essential for the proper functioning of hundreds of enzymes.
It plays a crucial role in various bodily functions. From promoting antioxidant enzymes to supporting brain function and boosting the immune system, zinc is a key player in maintaining good health.
Particularly recognised for its impact on the immune system, zinc is involved in the production and activity of immune cells, helping the body to fight infection. By promoting the formation of collagen, a protein essential for wound healing, zinc also plays a crucial role in cell regeneration.
As an essential component of antioxidant enzymes, zinc protects cells from damage caused by free radicals. Its importance for normal brain function, growth and development, as well as its contribution to reproductive health, underline the diversity of the benefits it provides.
Zinc is not limited to specific aspects of health, but extends its influence to the metabolism of carbohydrates, lipids and proteins, contributing to the smooth running of numerous enzymatic reactions. In addition, studies suggest that taking zinc supplements can potentially reduce the duration of cold symptoms.
THE ROLE OF ZINC
It is essential to the body, thanks in particular to its antioxidant and anti-inflammatory properties, which may explain some of its benefits when taken as a supplement.
Adequate zinc intake is crucial at every stage of life, from pregnancy to childhood and adulthood. It is essential for the proper functioning of the immune system, playing a part in the activity of innate and adaptive immune cells. It also helps regulate blood sugar levels, by supporting the function of beta cells in the pancreas and the absorption of glucose. In men, zinc is necessary for spermatogenesis and sperm mobility.
In neurological terms, zinc modulates the activity of NMDA receptors, which are known to be involved in the transmission of glutamate, a neurotransmitter that is often overactive in people suffering from depression. Zinc may also improve mood by stimulating the production of BDNF (Brain-Derived Neurotrophic Factor), a protein essential for neuronal plasticity.
A concrete example: a person suffering from chronic stress and fatigue could benefit from zinc supplementation to support their immunity and improve their mental resilience.
CHOICE OF ZINC SHAPES
Not all sources of zinc are equal, but don't worry, some are better assimilated by the body and offer optimal beneficial effects!
That's why we've selected the three best forms of zinc to ensure maximum absorption and enhanced efficacy
ZINC BISGLYCINATE
This chelated form ensures excellent bioavailability, limiting the digestive problems often associated with other forms of zinc. It is ideal for optimal assimilation and a prolonged effect in the body.
ZINC MONO-L-METHIONINE
Combined with an essential amino acid (methionine), it further improves its cellular assimilation and stability in the body. This form is particularly appreciated for its action on immunity, oxidative stress and cognitive function.
ZINC GLUCONATE
Well tolerated by the body, it is an effective source for supporting the immune system, skin health and the production of antioxidant enzymes.
WHY ARE THESE SHAPES IDEAL?
By combining zinc bisglycinate, zinc mono-L-methionine and zinc gluconate, our formula guarantees optimal absorption thanks to a synergy between different absorption channels (amino acid transporters and ZIP4). Unlike less effective forms such as zinc oxide, these three forms ensure maximum bioavailability and better retention in the body.
Thanks to this approach, you benefit from highly assimilable zinc, optimising its effects on immunity, metabolism, hormonal function and neuronal health.
More energy, better physiological balance and enhanced performance.
OPTIMISED ABSORPTION THANKS TO THREE COMPLEMENTARY FORMS OF MAGNESIUM
To optimise absorption without saturating a single pathway, we have selected three complementary forms of magnesium:
Magnesium bisglycinate is absorbed via active amino acid transport thanks to its link with glycine. It thus bypasses the TRPM6 and TRPM7 channels, avoiding saturation.
Magnesium malate uses both pathways: it passes in part through TRPM6 and TRPM7 channels, but a portion is also absorbed by passive diffusion between cells.
Magnesium citrate is highly soluble and mainly uses the transcellular pathway, passing through TRPM6 and TRPM7 ion channels.
By combining these three forms, we ensure optimised absorption by spreading assimilation over several mechanisms, without overloading a single pathway.
To optimise absorption without saturating a single pathway, we have selected three complementary forms of magnesium:
Magnesium bisglycinate is absorbed via active amino acid transport thanks to its link with glycine. It thus bypasses the TRPM6 and TRPM7 channels, avoiding saturation.
Magnesium malate uses both pathways: it passes in part through TRPM6 and TRPM7 channels, but a portion is also absorbed by passive diffusion between cells.
Magnesium citrate is highly soluble and mainly uses the transcellular pathway, passing through TRPM6 and TRPM7 ion channels.
By combining these three forms, we ensure optimised absorption by spreading assimilation over several mechanisms, without overloading a single pathway.
THE DIFFERENT ROUTES OF MAGNESIUM ABSORPTION
1. The transcellular (active) pathway: magnesium passes directly through intestinal cells via TRPM6 and TRPM7 ion channels. This pathway is effective, but limited, which means that it can be saturated if too much magnesium uses this mechanism at the same time.
2. The paracellular (passive) route: magnesium passes between the intestinal cells by a simple concentration gradient. This absorption depends on the amount of magnesium present in the intestine.
The exception is chelated magnesium biscgysinate. This magnesium has the ability to block the peptide and amino acid pathway (PEPT1). This enables it to be absorbed up to 70% more efficiently than magnesium oxide. Once in the intestinal cells, chelated magnesium bisglycinate is dissociated into free magnesium and glycine.
AN IDEAL COMBINATION FOR COMPREHENSIVE COVER
Their combination optimises three essential aspects: psychological well-being, digestive function and muscular health.
This trio works in synergy for better assimilation.
1. MAGNESIUM BISGLYCINATE
For the relaxation, sleep and nervous balance
This is a chelated form in which the magnesium is linked to two molecules of glycine, an amino acid with neurotransmitter properties.
By modulating the activity of GABA, the main inhibitory neurotransmitter in the nervous system, glycine promotes a state of relaxation and helps to manage stress more effectively. By reducing neuronal excitability, it also contributes to deeper, more restful sleep, improving the quality of rest. Its action on neurotransmitter regulation could also play a role in preventing depression and maintaining emotional stability. It is also involved in protein synthesis and muscle contraction, supporting muscle recovery and optimising overall muscle function.
2. MAGNESIUM CITRATE
To optimise digestion, metabolism and cell protection
Magnesium citrate is a form in which the magnesium is bound to citric acid, a compound naturally present in fruit and in cellular metabolism.
Thanks to its alkalinising effect, citric acid helps to regulate gastric acidity, promoting better absorption of nutrients and limiting digestive discomfort. It also has antioxidant and anti-inflammatory properties, acting as a heavy metal chelator, helping to reduce oxidative stress and preserve cell function. What's more, it plays an essential role in the Krebs cycle, a key process in energy metabolism that enables the production of ATP, thus ensuring an optimal supply of energy for the cells.
3. MAGNESIUM MALATE
For energy, recovery and cramp prevention
Magnesium malate is a form in which the magnesium is bound to malic acid, a key intermediate in the Krebs cycle.
Malic acid is an essential component of energy metabolism, helping to produce more ATP and reduce chronic fatigue.
It improves recovery after exercise, making it ideal for athletes and active people.
In addition eBy regulating electrolyte balance, it helps to reduce involuntary contractions and muscle fatigue.
Magnesium deficiency is often linked to neuromuscular disorders, and malate helps to optimise nerve transmission.
THE OVERALL BENEFITS OF MAGNESIUM
Magnesium is an essential nutrient and one of the most abundant minerals in the body. It acts as an electrolyte and cofactor in over 600 enzyme reactions.
It is essential for ATP production, glucose metabolism, DNA and protein synthesis, nerve conduction, bone health and cardiovascular regulation. It also plays a key role in the synthesis and activation of vitamin D.
Rather than having 'miraculous' effects, magnesium supplementation helps to correct deficiencies that may be responsible for various disorders.
MAGNESIUM AND BLOOD SUGAR REGULATION
One of the most important roles of magnesium is its impact on insulin sensitivity and glucose management. It is essential for the proper functioning of the beta cells in the pancreas, which control insulin production. When magnesium is in short supply, insulin secretion becomes ineffective, glucose accumulates in the blood and insulin resistance sets in.
Studies show that people with insufficient magnesium intake have a higher risk of developing type 2 diabetes. What's more, the chronic inflammation induced by a magnesium deficiency further aggravates insulin resistance, creating a vicious circle.
MAGNESIUM AND CARDIOVASCULAR HEALTH
Magnesium also acts as a regulator of intracellular calcium.
Why is this important? Because too much calcium in the muscle cells of the blood vessels leads to excessive contraction (vasoconstriction), which increases blood pressure. Conversely, a good balance of magnesium and calcium promotes vascular relaxation, which helps maintain normal blood pressure.
In addition, magnesium stimulates the production of nitric oxide (NO), a molecule that promotes the dilation of blood vessels and improves circulation. This is why people with a high intake of magnesium, through their diet or supplements, often have better cardiovascular health and a reduced risk of hypertension.
MAGNESIUM AND BONE HEALTH
Magnesium plays a key role in bone health, as 60 % of the body's magnesium is stored in the bones, where it contributes to bone formation and density. It is essential for the activation of vitamin D, which regulates the absorption of calcium, a mineral that is fundamental for strong bones. In addition, magnesium acts as a modulator of intracellular calcium, preventing its excessive crystallisation and favouring its deposition in bone rather than soft tissue. Magnesium deficiency is associated with an increased risk of osteoporosis and fractures, as it leads to disruption of calcium metabolism and a reduction in bone mineral density.
BRAIN MAGNESIUM AND STRESS
Magnesium plays a key role in the nervous system by influencing several neurotransmitters. It binds to NMDA receptors and blocks their excessive activation by glutamate, an excitatory neurotransmitter which, in excess, can promote migraines and cerebral hyperactivity.
It also acts as a modulator of GABA, a calming neurotransmitter, which explains why magnesium is often recommended to improve sleep and reduce stress. A lack of magnesium is also often associated with an increase in cortisol, the stress hormone, which disrupts glucose metabolism and encourages weight gain.
MAGNESIUM, INFLAMMATION AND IMMUNITY
Chronic low-grade inflammation is a major problem in modern diseases, from diabetes and cardiovascular disease to certain neurological pathologies. Magnesium has a natural anti-inflammatory action, as it regulates the production of pro-inflammatory cytokines such as IL-6 and TNF-α.
In other words, a good level of magnesium helps to reduce systemic inflammation and improve the immune response. This plays a crucial role in the prevention of chronic diseases and even in muscle recovery after exercise.
MAGNESIUM, MITOCHONDRIA AND ENERGY
Our cells need energy to function, and this energy is produced in the mitochondria, the cells' energy centres. Magnesium is essential for the production of ATP (the molecule that stores energy).
When magnesium is lacking, energy production is less efficient, which can lead to chronic fatigue and a slower metabolism. This is also one of the reasons why sportspeople and very active people have an increased need for magnesium.
THE ROLE OF MAGNESIUM
Magnesium mainly helps to correct imbalances that can be the cause of various metabolic, cardiovascular and neurological disorders. A balanced diet rich in magnesium is therefore one of the keys to preventing these problems and maintaining good overall health.
HOW CAN MAGNESIUM HELP YOU SLEEP BETTER?
Magnesium encourages the production of melatonin, the sleep hormone. It regulates the neurotransmitters that calm the nervous system, promoting a state of relaxation. Finally, it helps relax muscles, reducing physical tension.
1.PHYSIOLOGICAL ACTIONS OF MAGNESIUM
Magnesium promotes melatonin production mainly by acting on the enzyme serotonin N-acetyltransferase (AANAT), which converts serotonin into melatonin in the pineal gland. Without magnesium, this conversion is less efficient, which can lead to reduced melatonin production and disrupt the sleep cycle.
In addition, thanks to its N-methyl-D-aspartate (NMDA) receptor antagonist and gamma-aminobutyric acid (GABA) agonist action, it acts as a GABA-A receptor agonist.
However, apigenin has a more targeted and powerful action on GABA-A receptors than magnesium, making it a better candidate for promoting sleep and reducing anxiety. Magnesium, on the other hand, plays a more global role in neurophysiology, by stabilising neuronal excitability.
2. PHYSIOLOGICAL ACTIONS OF MAGNESIUM
Magnesium reduces neuronal excitability by blocking the entry of calcium into nerve cells. This promotes a state of relaxation, helping to improve sleep quality by making nerve cells less excitable. This is one of the mechanisms by which magnesium contributes to better sleep.
Magnesium could therefore regulate the sleep/wake cycle and promote good quality sleep. This is why it is often presented as a beneficial sleep supplement, used by some to combat insomnia and improve the quality or duration of sleep.
WHAT IS THE BEST MAGNESIUM?
There really is no such thing as the 'best' magnesium, as its effectiveness depends on a number of factors: the benefits sought, bioavailability and digestive tolerance. However, some forms are clearly better suited to the objectives being pursued.
HOW TO CHOOSE THE RIGHT MAGNESIUM?
For high bioavailability
Certain forms of magnesium are better absorbed by the body. In general, organic forms such as magnesium bisglycinate, citrate, malate, taurate and threonate are better absorbed than inorganic forms such as oxide or hydroxide, which are less effective.
For their digestive tolerance
Forms such as magnesium oxide or marine magnesium can have a strong laxative effect, making them unsuitable for daily supplementation. Bisglycinate, on the other hand, is very well tolerated and does not cause intestinal irritation.
CHOOSE YOUR MAGNESIUM ACCORDING TO YOUR OBJECTIVES
Muscle recovery and sports performance → Magnesium malate
Managing stress and improving sleep → Magnesium bisglycinate
Energy and nutrient absorption → Magnesium citrate or malate
Digestive support and transit → Magnesium chloride or oxide
Cardiovascular health and blood sugar regulation → Magnesium taurate
Cognitive good → magnesium threonate
THE DIFFERENT FAMILIES OF MAGNESIUM
There are 3 main families of magnesium: inorganic Organic and chelated
Inorganic magnesium: natural salts, but limited absorption
Inorganic magnesium corresponds to mineral salts without a carbon atom in their chemical structure. It occurs naturally in rocks, seawater and mineral deposits and can be found in various forms
INORGANIC MAGNESIUM
Magnesium oxide (MgO): Very high magnesium content (60% elemental magnesium), but poorly soluble in water and less than 10% absorbed. It is often used as a laxative rather than an effective supplement. Often found in low-end food supplements, as it is cheap.
Magnesium carbonate (MgCO₃): Slightly better solubility and absorption than oxide, but not yet the ideal. It has to be dissolved by gastric acid to release the Mg²⁺, which slows down its assimilation.
Magnesium chloride (MgCl₂): Highly soluble in water, better absorption (~30-40%), with a possible laxative effect at high doses. It is often used to rebalance electrolytes.
Magnesium sulphate (MgSO₄): Highly soluble, but average intestinal absorption (~30%). In high doses, it causes a rapid laxative effect, which is why it is often used as a medical purgative.
WHY IS THE ABSORPTION OF INORGANIC FORMS LIMITED?
Magnesium absorption depends on its solubility and the availability of free Mg²⁺ to pass through the intestinal wall. Poorly soluble salts (oxide, carbonate) release few Mg²⁺ ions, which reduces their uptake.
Even the highly soluble forms (chloride, sulphate) can cause problems because the excess unabsorbed ionic magnesium attracts water by osmosis, which has a laxative effect and limits absorption. So it's not great...
ORGANIC MAGNESIUM
Organic magnesium is bound to an organic molecule containing carbon, generally an amino acid or an organic acid. This bond completely changes the way it is absorbed by the body.
- Magnesium bisglycinate (linked to glycine): Very well absorbed (~70-80%), low laxative effect as it uses amino acid transporters to enter cells. Excellent option for reducing stress and improving sleep.
- Magnesium malate (linked to malic acid) : Good absorption (~50-60%), promotes energy production via the Krebs cycle, ideal for athletes and people suffering from chronic fatigue.
- Magnesium citrate (bound to citric acid) : High absorption (~30-50%), but possible laxative effect in high doses. Useful for boosting energy and improving digestion.
- Magnesium lactate (linked to lactic acid) : Good bioavailability (~40-50%), used medicinally for magnesium-deficient people.
WHY ARE ORGANIC FORMS BETTER ABSORBED?
Unlike inorganic salts, organic magnesium is absorbed via a different route:
Amino acid transporters (bisglycinate) enable more efficient absorption.
Organic acids (malate, citrate) improve the solubility of magnesium and facilitate its passage through the intestinal mucosa.
Less magnesium remains in free form in the intestine, reducing the risk of a laxative effect.
CHELATED MAGNESIUM IS AN ADVANCED FORM OF ORGANIC MAGNESIUM
Chelated magnesium is a specific form of organic magnesium, where the Mg²⁺ ion is bound to an amino acid, usually glycine. This bond stabilises the magnesium, improves its intestinal absorption and reduces the laxative effect often associated with inorganic forms.
Chelated magnesium bisglycinate is one of the most bioavailable and well-tolerated forms. Thanks to its chelation with glycine, it uses amino acid transporters, enabling it to avoid competition with other minerals and to be absorbed efficiently by the body.
THINGS TO KNOW!
Some manufacturers market low-quality magnesium bisglycinates, which are really just a mixture of inorganic magnesium (e.g. magnesium oxide) and glycine, with no real chelation. These products are much less absorbable and may cause more digestive side-effects.
That's why it's essential to choose a magnesium bisglycinate clearly labelled "chelated", to ensure optimum absorption and maximum effectiveness.
WHY DO SOME MAGNESIUMS HAVE A LAXATIVE EFFECT?
This effect is generally due to inorganic magnesium such as magnesium oxide or sulphate.
This can happen for two reasons:
- The osmotic effect linked to the presence of unabsorbed magnesium (elemental form in salt form, as in magnesium oxide).
- The osmotic effect linked to a high concentration of ionic magnesium (free Mg²⁺) which is not absorbed, as in magnesium sulphate or chloride).
Magnesium oxide and magnesium carbonate are poorly absorbed by the body, mainly due to their low solubility in water. As their dissolution is limited, they have difficulty dissociating into magnesium ions (Mg²⁺) in the intestine, which reduces their bioavailability.
By remaining in the form of undissolved salts, they cannot be directly absorbed by the magnesium transporters (TRPM6/7). As a result, a large proportion of these salts remain in the intestine, where they attract water by osmotic effect, leading to softening of the stools and a laxative effect.
In addition, inorganic magnesium salts (such as oxide and carbonate) often have a high elemental magnesium content. This means that when they are consumed in large quantities, the intestinal absorption capacity is rapidly saturated. Excess magnesium that is not absorbed then remains in the intestine, amplifying the osmotic and laxative effect.
This is why these forms of magnesium are not the best for correcting a deficiency, despite their high content of elemental magnesium.
WHO IS MOST LIKELY TO BE MAGNESIUM DEFICIENT?
- Stress and anxiety: Magnesium regulates the nervous system by promoting the production of GABA, thereby reducing anxiety and improving sleep.
- Athletes: It plays a key role in muscle contraction, recovery and energy production (ATP), helping to prevent cramp and muscle fatigue.
- People suffering from chronic fatigue: Magnesium is essential for energy production and combats physical and mental exhaustion.
- People with sleep problems: By reducing stress and promoting muscle relaxation, it helps to improve sleep quality.
- Women prone to PMS (premenstrual syndrome): Magnesium relieves menstrual cramps, irritability and water retention by regulating hormones and muscle contraction.
- The elderly: Ageing reduces magnesium absorption, which can aggravate conditions such as osteoporosis, hypertension and muscle loss.
- Migraine sufferers: Studies show that magnesium deficiency is common in migraine sufferers, and supplementation can reduce the frequency and intensity of attacks.
- People with an unbalanced diet: Excessive consumption of coffee, alcohol, sugar or processed foods depletes magnesium reserves.
- Diabetics or pre-diabetics: Magnesium improves insulin sensitivity and helps regulate blood sugar levels, thereby reducing the risk of metabolic complications.
- People suffering from hypertension: Magnesium promotes vasodilation and relaxation of the blood vessels, helping to regulate blood pressure.
