NAD+: strategies against its cellular decline
Do you often feel tired despite an impeccable lifestyle? Have you noticed a drop in your muscle recovery or a reduction in your sporting performance? It could be that your body lacks NAD+, this important molecule in the production of energy in your cells. In this article, we will explore in detail the level of NAD+, its crucial role in energy metabolism, and how to optimise your healthy levels of NAD to improve your cellular health and vital functions.
- NAD+ is essential for energy production ATP: It acts as an electron carrier in the mitochondria, enabling the synthesis of ATP, the energy used by the cells.
- Natural decline in NAD+ from the age of 30 With age, its production decreases and its degradation increases, leading to fatigue, reduced performance and accelerated cell ageing.
- Precursors are the best solution NR (Nicotinamide Riboside) and NMN (Nicotinamide Mononucleotide) enable the body to manufacture NAD+ efficiently, unlike pure NAD+ which is poorly absorbed.
- The NAD+/NADH balance is crucial A good redox balance supports energy production, slows cell ageing and improves physical and mental recovery.
- Stable forms such as NADH in gastro-resistant capsules This formulation protects NADH all the way to the intestine, guaranteeing optimal absorption and lasting support for cellular health.
A reminder of what NAD is
What is NAD+ and why is it so important?
NAD⁺, for Nicotinamide Adenine Dinucleotide, is a coenzyme present in all our cells. Its main function is to transport electronsThis enables it to be involved in more than 500 enzymatic reactions that are vital to our body. This molecule is therefore a fundamental pillar of healthy cell function.
The two forms of NAD and their balance
NAD exists in two forms: NAD⁺, which captures electrons, and NADH, which transfers them to the mitochondria. A balance between these two forms is to maintain a healthy energy metabolism to maintain a healthy energy metabolism. An imbalance can disrupt energy production and accelerate cell ageing.
NAD+: a key player in energy production
NAD⁺ acts as an electron transporter, capturing energy from nutrients and delivering it to the mitochondria, veritable energy factories. This exchange enables the synthesis of ATP, the energy currency of cells. A deficiency in NAD⁺ directly reduces the ability to produce energy.
Multiple roles beyond energy production
NAD⁺ is involved in DNA repair, the proper functioning of mitochondria and the control of gene expression. These multiple functions make it a strategic target for cellular health. By facilitating the repair of cellular damage, it contributes to directly to longevity and the prevention of age-related illnesses.
The decline in NAD+ with age
From the age of 30, our bodies produce less NAD⁺ while degrading more via enzymes such as CD38. This dual pressure, which can be described as age-related, explains the fall in NAD⁺ levels, which is particularly marked if lifestyle habits are inappropriate. This decline affects gradually restore cellular vitality.
Consequences of insufficient NAD+ levels
Low levels of NAD⁺ result in reduced energy, slowed muscle recovery, persistent mental fog, loss of skin radiance, a temperamental metabolism and increased chronic inflammation. These effects are visible at both cellular and systemic levels, underline the importance of this coenzyme for overall health.
Symptoms of NAD+ deficiency
The signs of an inadequate level of NAD+ include :
- Reduced energy Fewer small NAD+ trucks to transport the energy hidden in the food to the mitochondria
- Slower muscle recovery Less DNA repair and effective cell regeneration
- Persistent mental fog NAD+/NADH imbalance affects intellectual clarity
- Loss of skin radiance Accelerated skin ageing is a sign of advanced cell ageing
- Capricious metabolism: Insulin resistance and weight gain despite efforts
Detection of a low NAD+ level is based primarily on observation of these symptoms, although a blood sampling remains the most reliable method to accurately assess its status.
| Main function | Mechanism of action | Impact on health |
|---|---|---|
| Power generation | Acts as an electron transporter in the mitochondrial respiratory chain, contributing to ATP synthesis | Fundamental to maintaining a healthy energy metabolism and sustained vitality |
| DNA repair | Activates sirtuins, proteins that help regulate ageing and reduce age-related decline | Contributes to cell stability, cell resilience and longevity |
| Cell signalling | Influences cell communication and the regulation of gene expression | Improves cognitive function and offers protection against neurodegenerative diseases |
| Immune system support | Helps the body to respond effectively to infections and inflammation | Reduces the risk of cardiovascular problems by preserving cell function and controlling inflammation |
- Increases NAD+ levels for better cell function
- Improves physical endurance and performance
- Helps reduce fatigue and naturally boosts energy levels
- Contributes to cell longevity and overall health
- Laboratory tested for 99.9% purity and GMP and HACCP certified
- Vegetarian capsules with a high concentration of NAD+.
Optimising NAD+ levels: approaches and strategies
The importance of NAD+ precursors in increasing its levels
NAD+ precursors are molecules that your body knows how to convert into NAD+. NAD⁺ precursors are often sold and used for their supposed effects on longevity, but it's important to inform yourself about the potential risks, as explained in this detailed article. These molecules go through a series of metabolic steps before they produce NAD+ that can be used by your cells. Contrary to what some sellers claim, taking Pure NAD+ is not very effective. Your digestive system breaks down this molecule before it can be used by your cells. Precursors such as NR and NMN, on the other hand, pass through this process unhindered, enabling your cells to produce NAD+ directly from within.
The main precursors and their comparative effectiveness
Nicotinamide Riboside (NR) is a direct precursor of NAD+ that easily crosses cell barriers. Once in the cell, it is converted to NAD+ via a simple metabolic pathway. Studies show that it improves blood levels of NAD+. effectively. It is particularly relevant for sportspeople looking to improve their performance, as its effects are felt fairly quickly. You can consult our scientific analysis here.
Nicotinamide Mononucleotide (NMN) is another NAD+ precursor that converts directly to NAD+ without any intermediate steps. It is highly effective in increasing NAD+ levels in the body. However, in Europe, its marketing is prohibited. *But here's the problem, on the market...* You can consult our quality product here. It is classified as "Novel Food", which means it cannot be sold without prior authorisation. It is classified as 'Novel Food', which prevents it from being sold without prior authorisation. Fortunately, NR is still available and is similarly effective in increasing NAD+ levels.
The role of vitamin B3 and its derivatives
Vitamin B3, in its nicotinamide and niacin forms, acts as a NAD+ precursor with a more gradual action. It is integrated into the metabolic pathways that lead to the production of NAD+, but its effect is slower and more long-lasting. Niacin can cause hot flushes in some people, making it less comfortable to use than nicotinamide.
Nicotinamide and niacin, two forms of vitamin B3, have different characteristics. The nicotinamide is better tolerated and does not cause hot flushes. It maintains stable levels of NAD+ over time. Niacin, although effective, can have unpleasant side effects for some people. It remains useful in certain specific medical contexts, but is less suitable for everyday use by athletes.
How many NMN should I take a day?
Your recommended dose
The NAD+/NADH balance: the key to optimal supplementation
Why redox balance is important for energy metabolism
NAD+ and NADH are two forms of the same molecule, essential for metabolism. Their redox balance has a direct influence on energy production and cellular health.
An imbalance between NAD+ and NADH disrupts energy production, accelerates cell ageing and affects physiological functions. This balance regulates all metabolic processes and the response to oxidative stress.
The value of NADH in supplementation
NADH helps maintain a healthy balance between the two forms of NAD. It is involved in electron transport in mitochondria for optimum energy production.
Some of the NADH ingested is converted into NAD+ by specific enzymes. This mechanism preserves theredox balance, promoting balanced cell function over the long term.
Stability challenges and solutions for NADH supplementation
NADH is extremely sensitive to oxidationIts complex structure requires protection to preserve its integrity. Its complex structure requires protection to preserve its integrity.
Gastro-resistant capsules protect NADH from gastric acidity. They ensure that it is released in the small intestine, where absorption is at its highest. To find out more about our approach, see on our About page.
NAD+ is more than just cellular fuel: it's the architect of your vital energy. From the age of 30, its reserves are eroded - but the solution lies in proven precursors such as NR and NADH, combined with gastro-resistant capsules. At Dix, we've designed a balanced formula to restore this fundamental bioenergy lever. Because preserving your NAD+ means invest in years optimal cellular performance - and give you the strength to stay on track towards your goals.
The NMN DIX: safety and quality at the heart of our production
In view of the studies presented and the importance of the quality of the NMN to avoid any side effects, you can see how important the choice of your supplement is.
Our NMN DIX complies with the highest safety standards set out in clinical studies. Our production process rigorously follows conservation and manufacturing recommendations:
- GMP and HACCP certification (guaranteeing strict manufacturing standards)
- Enzyme production for optimum bioavailability
- Systematic laboratory tests for 99.9% purity
- Total absence of heavy metals
- Packaged for optimum conservation
As the studies by Okabe et al. and Yi et al. have shown, the purity and quality of NMN are essential to guarantee its efficacy while minimising the risk of side effects.
Our enzymatic rather than chemical manufacturing process produces a product that is closer to the natural form of NMN, which may explain the lack of adverse effects reported by our users.
The safety of a supplement depends directly on the quality of its manufacture
Scientific publications on NMN safety
- "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomised, multicentre, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial." (Major study on the safety of NMN at different doses) DOI: 10.1007/s11357-022-00705-1
- "The safety and anti-ageing effects of nicotinamide mononucleotide in human clinical trials: an update" (Full review of safety studies on NMN) DOI: 10.1016/j.advnut.2023.08.008
- "Improved physical performance parameters in patients taking nicotinamide mononucleotide (NMN): A systematic review of randomised controlled trials" (In-depth analysis of safety and effectiveness) DOI: 10.7759/cureus.65961
- "Oral administration of nicotinamide mononucleotide is safe and effectively increases blood levels of nicotinamide adenine dinucleotide in healthy subjects". (Clinical study on the safety of oral administration) DOI: 10.3389/fnut.2022.868640
- "Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men". (First clinical study on the safety of NMN) DOI: 10.1507/endocrj.EJ19-0313
- "Effect of taking nicotinamide mononucleotide for 12 weeks on sleep quality, fatigue and physical performance in older Japanese adults". (Study on long-term effects) DOI: 10.3390/nu14040755
