Buy Apigenin 100mg: Restorative Sleep & French Lab - DIX

Apigenin promotes the activation of GABA receptors, which play a key role in reducing neuronal excitability and preparing the central nervous system for sleep. Activation of these receptors allows chloride ions to enter nerve cells, decreasing their excitability by hyperpolarizing the neurons. Conversely, calcium has the opposite effect by increasing neuronal excitability. By reducing this excitability, GABA also helps to curb excessive activity in circuits involved in stress and anxiety. Animal studies show that it may protect cells from damage caused by toxins and bacteria, thereby limiting genetic mutations. It also helps neutralize free radicals, inhibit certain enzymes linked to tumor growth, and stimulate detoxifying enzymes like glutathione. Its anti-inflammatory effect could also play a role in mental health, brain function, and strengthening the immune system. For example, by acting on oxidative stress, it could help improve sleep quality and stress management. Other preclinical studies on cells and animals show that apigenin could have beneficial effects on anxiety and brain activity. For example, a study in mice found that a dose of 3 to 10 mg/kg of body weight reduced anxiety without causing sedation. Other research also suggests a neuroprotective effect, likely related to improved mitochondrial capacity, with concentrations ranging from 1 to 33 micromolar. However, few clinical studies have confirmed these effects in humans. Two promising studies have investigated apigenin as a component of chamomile (Matricaria recutita) for relieving anxiety and migraine. In one of them, participants suffering from both anxiety and depression took 200 to 1,000 mg of chamomile extract per day (standardized to 1.2% apigenin) for 8 weeks and reported an improvement in their symptoms. Another crossover study showed that a chamomile-based gel (0.233 mg of apigenin per gram) applied topically reduced pain, nausea, vomiting, and sensitivity to light and noise within 30 minutes in people suffering from migraines.

Often consumed for its calming and relaxing properties, thanks to its positive effects on GABA receptors. Apigenin thus helps improve sleep and falling asleep, as well as reduce nighttime awakenings. Its beneficial aspects are more observed in people who are naturally anxious and stressed. In summary, people who worry easily about the slightest detail. However, apigenin has shown much more than benefits on sleep. Although there are still few human clinical trials studying the effects of apigenin as a unique compound, preclinical studies have suggested that apigenin could improve outcomes in anxiety, brain function, oxidative stress, inflammation, and hormonal regulation such as testosterone, estrogen, and cortisol.

DIX uses a natural source apigenin extract, unlike most products on the market that are derived from synthesis. Each capsule provides 100 mg of apigenin, with a high active ingredient content and optimized absorption. Our apigenin is tested by independent laboratories.

Our chamomile extract comes solely from the flower, allowing you to obtain the benefits of chamomile, but also Apigenin which is naturally present in our extract. You can therefore benefit from its properties on physical and mental well-being and optimize the quality of your sleep.

Daily consumption of apigenin can induce a feeling of relaxation and well-being, promoting better sleep, both in quality and quantity.

A reduction in stress can also be observed. Some users report a decrease in anxiety, better emotion management, as well as an improvement in mental and physical recovery.

With regular intake, it is possible to feel an anti-inflammatory effect, a reduction in mental fatigue, and, in some cases, better hormonal stability. Subtle effects on vitality and concentration may also be observed,

Results may vary depending on individual factors such as age, lifestyle, and overall health condition.

No toxicity has been reported following the dietary consumption of apigenin. However, it is important to note that extremely high doses (30 to 100 mg/kg of body weight) can lead to a sedative effect as a side effect.

Sleep is of paramount importance for our health and well-being. It plays a major role in the nervous, hormonal, and physical systems. It is therefore important to optimize it. Apigenin is scientifically proven to support healthy sleep, while chamomile relaxes and promotes physical and mental well-being.

Many people are unaware, but when apigenin is isolated from its natural source, its bioavailability can be reduced. This means that the body may have more difficulty absorbing it and fully benefiting from it. Studies have shown that apigenin loses stability when isolated.

Conversely, when it is preserved in its natural environment, it is accompanied by cofactors and bioactive compounds that work synergistically to improve its absorption by the body. In other words, chamomile extract allows for better assimilation and increased effectiveness of apigenin compared to an isolated (synthetic) form. This ensures not only optimal absorption but also maximized soothing and relaxing benefits.

By choosing our chamomile-extracted apigenin, you are opting for a more natural and bioavailable form, making it a superior solution.

Apigenin could contribute to the reduction of cortisol, the stress hormone. An in vitro study on human adrenal cells showed that a flavonoid mixture containing apigenin, at concentrations ranging from 12.5 to 100 micromolar, reduced cortisol production by up to 47.3% compared to control cells.

In mice, apigenin extracted from Cephalotaxus sinensis (a plant from the plum yew family) improved the physiological response to insulin. However, these results have not been reproduced in humans. In a study where participants consumed a black pepper drink containing apigenin, followed by a wheat bread-based meal, no significant difference in blood sugar and insulin was observed compared to the control group.

Apigenin could also influence reproductive hormones such as testosterone and estrogens. Preclinical studies suggest that it modifies the activity of certain enzymes involved in testosterone regulation, even at low concentrations (5 to 10 micromolar).

Its effect on cancer cells has also been studied. When exposed to 20 micromolar apigenin for 72 hours, breast cancer cells showed an inhibition of their proliferation via control of estrogen receptors. Similarly, ovarian cells treated with apigenin showed inhibition of aromatase activity, a mechanism that could play a role in the prevention and treatment of breast cancer. However, it remains uncertain how these effects could translate into an effective oral dose in humans.