Aging better with apigenin, what research says

Are you looking for a natural and effective solution to combat aging?

Apigenin, a compound found in certain plants like chamomile, is gaining increasing interest in the scientific community. Let’s explore together why this flavonoid could be your new anti-aging ally.

What is apigenin and where can it be found?

Apigenin is a natural flavonoid, belonging to the polyphenol family, primarily found in fruits and vegetables. You can find it in notable quantities in parsley, celery, onions, chamomile, thyme, oregano, basil, as well as in certain beverages like tea, beer, and wine.

If you wish to delve deeper into the topic of apigenin, I invite you to read our detailed article that explains its molecular composition and biochemical properties in depth.

But what particularly interests us today is its anti-aging potential…

How does apigenin act on aging?

Apigenin combats aging primarily by increasing NAD+ levels in our body, an essential molecule that naturally decreases with age.

This action is complemented by powerful anti-inflammatory and antioxidant effects that, together, help slow down the aging process.

You might be wondering what NAD+ is? It’s a molecule (nicotinamide adenine dinucleotide) that plays a crucial role in our cells’ energy production. Imagine it as a rechargeable battery powering your cells! Unfortunately, with age, our NAD+ levels drop significantly, affecting our energy and vitality.

Apigenin helps maintain these levels by inhibiting an enzyme called CD38, which typically consumes NAD+. At the mitochondrial level (the powerhouses of our cells), apigenin does remarkable work. Not only does it improve their function, but it also helps protect them from age-related damage.

Chronic inflammation and oxidative stress are two other aspects of aging that apigenin effectively combats. It acts like a firefighter extinguishing small fires of inflammation in your body while neutralizing free radicals that can damage your cells.

Let’s see what scientific studies tell us…

What do scientific studies say about apigenin?

Research on apigenin shows particularly promising results in animal studies, especially regarding longevity and age-related diseases. However, there is currently a caveat, as clinical studies in humans remain limited, although initial results are encouraging.

Animal studies

Researchers have conducted fascinating studies on different animal models. For example, in C. elegans worms (a commonly used research organism), administering apigenin at a concentration of 200-400 μg/mL significantly increased their lifespan.

It also improved their resistance to oxidative stress (something already known for Apigenin) by regulating the expression of several important aging-related genes.

In mice, the results are equally interesting. A study showed that orally administered apigenin at 300-900 mg/kg improved learning and memory in aged mice. Researchers also observed protection against oxidative damage and improved cerebral blood flow.

Human studies

On the clinical side, research primarily uses chamomile extract, which contains about 5% to 25% apigenin.

An 8-week study using 500 mg of extract three times a day showed significant improvements in anxiety and blood pressure in elderly participants. Other studies have highlighted apigenin’s role in sleep, on the heart, and in combating oxidative stress. Sleep being an important factor for health, good sleep will improve your quality of life, and thus your way of aging.

What questions can we ask based on these studies?

Research has the advantage of answering certain questions but also sometimes raises others. Here are the questions you most often ask about apigenin and anti-aging.

Does apigenin perform better than NMN for anti-aging?

Apigenin and NMN act differently on aging, and it would be inaccurate to say that one is better than the other. Clinical studies on NMN are more numerous and standardized, while apigenin has the advantage of being more natural and accessible in the diet.

NMN acts directly as a precursor to NAD+, with clinical studies showing significant increases in blood NAD+ levels (up to 2.5 times) after supplementation. Apigenin, on the other hand, acts indirectly by inhibiting CD38, which helps preserve existing NAD+ levels.

Clinical studies on NMN are more advanced, with well-established dosages (250-500 mg/day) and promising results on muscle strength and metabolism. In contrast, apigenin shines with its versatility: it combines its effects on NAD+ with anti-inflammatory and antioxidant properties that NMN does not possess.

Can apigenin be combined with other anti-aging supplements?

Yes, and it’s even highly recommended!
Apigenin works particularly well in synergy with other natural compounds. Research shows that its combination with quercetin and resveratrol creates a particularly powerful anti-aging effect.

Quercetin, found in red onions and apples, shares a similar chemical structure with apigenin, except for two additional hydroxyl groups.

This similarity allows them to work in tandem to amplify their antioxidant effects. As for resveratrol, found notably in red grapes and wine, it perfectly complements the action of apigenin by targeting complementary cellular signaling pathways. Other interesting combinations include vitamin C, which helps recycle flavonoids like apigenin⟧PH5⟧, and omega-3 fatty acids, which can enhance its absorption. (A traditional Mediterranean diet naturally combines these elements).

What is the optimal dose of apigenin?

Studies suggest that a daily intake of 50 to 100 mg of apigenin would be beneficial. (This dose can be achieved through a diet rich in herbs and vegetables)

Is apigenin safe in the long term?

Available studies show an excellent safety profile, especially through the consumption of apigenin-rich foods. However, as an isolated supplement, the very long-term effects remain to be studied.

How to maximize the benefits of apigenin?

Favor natural food sources and combine them with a healthy lifestyle: quality sleep, regular exercise, and stress management. (Apigenin is better absorbed with a meal containing healthy fats)

In conclusion: our apigenin, an anti-aging aid

Scientific studies, including the one on neurovascular coupling (see the study), demonstrate the remarkable effectiveness of apigenin in combating cellular aging. This in-depth research reveals how apigenin actively protects our brain cells – it is precisely for these exceptional anti-aging properties that we have developed our unique formula, which combines perfectly with our NMN to maximize NAD+ production and amplify anti-aging effects. Our chamomile extract stands out for its exclusive flower extraction process, where apigenin reaches its maximum natural concentration. This approach, unlike products using synthetic apigenin or whole plant extracts, preserves the natural synergy of bio-active compounds. (The flowers contain up to 1.2% natural apigenin in its most bioavailable form) The anti-aging effectiveness of our product is based on multiple mechanisms of action: apigenin preserves your NAD+ levels by inhibiting CD38, while our NMN directly increases them. This dual action, combined with combating oxidative stress and chronic inflammation, creates a powerful synergy against aging. More remarkably, our natural apigenin works in perfect complementarity with NMN to optimize your cellular defenses. For optimal anti-aging effect, our formula integrates seamlessly into your daily routine. (Recommendation: 1-2 capsules of apigenin per day with your NMN during the meal). By choosing our apigenin-NMN duo, you opt for a natural and complete solution, whose anti-aging effectiveness is validated by science, to sustainably preserve your youth.