Age better with chamomile extract (Apigenine)
Are you looking for a natural and effective solution to combat ageing?
Apigenin, a compound found in certain plants such as camomile, is attracting growing interest in the scientific community. Let's find out why this flavonoid could be your new anti-ageing ally.
- Main anti-ageing mechanism NAD+: It increases NAD+ levels by inhibiting the CD38 enzyme, a crucial mechanism for slowing down cell ageing.
- Triple Action It combines anti-inflammatory, antioxidant and mitochondrial protective properties, three essential aspects in the fight against ageing.
- Scientific evidence Animal research shows a significant increase in lifespan and improved cognitive function.
- Synergy It works particularly well in combination with NMN and other antioxidants such as quercetin and resveratrol.
- Brain Protection It specifically protects brain cells against ageing and neurodegenerative diseases.
- Safety in use : Studies show an excellent safety profile.
- Impact on sleep It improves sleep quality, a crucial factor in the anti-ageing process.
What is apigenin and where can it be found?
L'apigenin is a natural flavonoid belonging to the polyphenol family, found mainly in fruit and vegetables. You can find it in significant quantities in parsley, celery, onions, camomile, thyme, oregano and basil, as well as in certain drinks such as tea, beer and wine.
If you'd like to find out more about apigenin, take a look at our detailed article explaining its molecular composition and biochemical properties.
But what particularly interests us today is its anti-ageing potential...
- Powerful antioxidant of natural 100% origin
- Positive influence on biological rhythms
- Supports mental well-being and stress management
- Extracted exclusively from flowers for optimum bioavailability
How does apigenin affect ageing?
L'apigenin fights ageing mainly by increasing the levels of NAD+ in our bodies, an essential molecule that naturally decreases with age.
This action is complemented by powerful anti-inflammatory and antioxidant effects, which together help to slow down the ageing process.
You may be wondering what NAD+ is. It's a molecule (nicotinamide adenine dinucleotide) that plays a crucial role in our cells' energy production. Think of it as a rechargeable battery that powers your cells! Unfortunately, as we age, our NAD+ levels drop considerably, affecting our energy and vitality.
L'apigenin is thought to help maintain these levels by inhibiting an enzyme called CD38, which normally consumes NAD+. In the mitochondria (the energy centres of our cells), l'apigenin does a remarkable job. Not only does it improve their function, it also helps to protect them from age-related damage.
Chronic inflammation and oxidative stress are two other aspects of ageing that theapigenin already fights effectively. It acts like a fireman, putting out the small fires of inflammation in your body, while neutralising the free radicals that can damage your cells.
Let's see what the scientific studies tell us...
What do scientific studies tell us about apigenin?
Research intoapigenin are showing particularly promising results in animal studies, especially in terms of longevity and age-related diseases. On the downside, clinical studies in humans are still limited, although the initial results are encouraging.
Animal studies
Researchers have carried out some fascinating studies on different animal models. For example, in C. elegans worms (an organism commonly used in research)the administration ofapigenin at a concentration of 200-400 μg/mL significantly increased their lifespan.
It also improved their resistance to oxidative stress (something we already knew about Apigenin) by regulating the expression of several important genes linked to ageing.
The results in mice are just as interesting. One study showed that apigenin, administered orally at 300-900 mg/kg, improved learning and memory in aged mice. Here too, the researchers observed protection against oxidative damage and an improvement in cerebral blood circulation.
Human studies
In clinical studies, research has mainly used chamomile extract, which contains between 5% and 25% ofapigenin.
An 8-week study using 500 mg of extract three times a day showed that significant improvements in anxiety and blood pressure in elderly participants. Other studies, however, have shown that the role of apigenin in sleepon the heart Sleep is an important factor in health, so a good night's sleep will improve your quality of life, and therefore the way you age.
What questions can we ask ourselves based on these studies?
Research has the advantage of answering certain questions, but it also sometimes leads to others. Here are the questions you most often ask about apigenin and anti-ageing.
Is apigenin better than NMN for anti-ageing?
L'apigenin and the NMN act differently on ageing, and it would be inaccurate to say that one is better than the other. Clinical studies on NMN are more numerous and standardised, while apigenin has the advantage of being more natural and accessible in the diet.
NMN acts directly as a precursor to NAD+, with clinical studies showing significant increases in blood levels of NAD+. (up to 2.5 times) after supplementation. L'apigeninacts indirectly by inhibiting CD38, thereby preserving existing NAD+ levels.
Clinical studies on NMN are more advanced, with well-established dosages (250-500 mg/day) and promising results on muscle strength and metabolism. On the other handapigenin stands out for its versatility: it combines its effects on NAD+ with anti-inflammatory and antioxidant properties that NMN does not possess.
Can apigenin be combined with other anti-ageing supplements?
Yes, and we strongly recommend it!
L'apigenin works particularly well in synergy with other natural compounds. Research shows that its combination with quercetin and the resveratrol creates a particularly powerful anti-ageing effect.
La quercetinfound in red onions and apples, shares a similar chemical structure toapigeninwith the exception of two additional hydroxyl groups.
This similarity allows them to work in tandem to amplify their antioxidant effects. As for resveratrolpresent in red grapes and wine, perfectly complements the action ofapigenin by targeting complementary cell signalling pathways.
Other interesting combinations include vitamin C, which helps to recycle flavonoids such asapigeninand omega-3 fatty acids, which can improve its absorption. (A traditional Mediterranean diet naturally combines these elements).
What is the optimal dose of apigenin?
Studies suggest that a daily intake of 50 to 100 mg ofapigenin would be beneficial. (This dose can be reached by eating a diet rich in aromatic herbs and vegetables)
Is apigenin safe in the long term?
The available studies show an excellent safety profile, particularly through the consumption of apigenin-rich foods. However, as an isolated supplement, the very long-term effects remain to be studied.
How to maximise the benefits of apigenin?
Favour natural food sources and combine them with a healthy lifestyle: quality sleep, regular exercise and stress management. (Apigenin is best absorbed with a meal containing healthy fats)
In conclusion: our apigenin, an anti-ageing aid
Scientific studies, in particular that on neurovascular coupling (see the study), demonstrate the remarkable effectiveness of theapigenin in the fight against cell ageing. This in-depth research reveals how apigenin actively protects our brain cells - it is precisely for these exceptional anti-ageing properties that we have developed our unique formula, which combines perfectly with our NMN to maximise NAD+ production and amplify the anti-ageing effects.
Our chamomile extract is distinguished by its exclusive flower extraction processwhere apigenin reaches its maximum natural concentration. This approach, unlike products using synthetic apigenin or whole plant extracts, preserves the natural synergy of the bio-active compounds. (Flowers contain up to 1.2% of natural apigenin in its most bioavailable form)
The anti-ageing effectiveness of our product is based on multiple mechanisms of action: apigenin preserves your NAD+ levels by inhibiting CD38, while our NMN directly increases them. This dual action, combined with the fight against oxidative stress and chronic inflammation, creates a powerful anti-ageing synergy. Even more remarkable, our natural apigenin works in perfect harmony with NMN to optimise your cellular defences.
For optimum anti-ageing benefits, our formula can be perfectly integrated into your daily routine. (Recommendation: 1-2 capsules of apigenin per day with your NMN during a meal). By choosing our apigenin-NMN duo, you are opting for a natural, complete solution whose anti-ageing effectiveness has been validated by science, to preserve your youthful appearance over the long term.
Scientific publications on apigenin and ageing
- "The flavonoid apigenin protects cerebral neurovascular coupling against beta-amyloid-induced toxicity in mice". (This study shows the protective effects of apigenin on the ageing brain) DOI: 10.3233/JAD-2010-101593
- "Behavioural characterisation of the flavonoids apigenin and chrysin (Documentation of the effects of apigenin on cognitive functions) DOI: 10.1016/S0367-326X(00)00186-6
- "Specific dietary (poly)phenols are associated with sleep quality in a cohort of Italian adults". (Study on the effects of apigenin on sleep, a key factor in ageing) DOI: 10.3390/nu12051226
