NAD
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DIX: Always at the forefront of innovation.
We've designed an advanced formula that effectively optimises your NAD⁺ levels while maximising its benefits on cellular and energy metabolism. Thanks to an in-depth understanding of the body's mechanisms, our supplement rapidly and sustainably increases NAD⁺, while ensuring an optimal balance between NAD⁺ and NADH, essential for proper cellular function.
An imbalance in the NADH/NAD⁺ ratio can be detrimental, particularly in the case of mitochondrial dysfunction or pathologies affecting cellular metabolism. This imbalance can reduce ATP production, increase oxidative stress and have a negative impact on overall health.
Our formula, carefully adjusted to regulate this ratio, raises NAD⁺ levels while supporting the redox cycle through the controlled supply of NADH. A perfect synergy for optimal cellular energy and lasting well-being.
The way your body works can be compared to a power station that converts nutrients into energy. For this system to function optimally, it relies on an essential molecule: Nicotinamide Adenine Dinucleotide (NAD). Present in all living cells, this coenzyme plays a fundamental role in energy and cellular metabolism.
In the absence of NAD, our cells would immediately stop functioning, and we would die within seconds.
NAD is a molecule known as a dinucleotide, as it is made up of two units: one containing a nucleic base adenine, the other a nicotinamide (a form of vitamin B3). It exists in two main forms: NAD⁺, which is its oxidised form, and NADH, which is its reduced form.
Its main role is to act as an electron transporter, facilitating the redox reactions essential for energy production. NAD⁺ acts as an oxidant, capturing electrons from nutrient metabolism, while NADH acts as a reductant, transporting these electrons to the electron transport chain in the mitochondria to produce ATP, the main source of cellular energy.
Without this process, your cells would find it much harder to generate the energy they need to carry out their vital functions. After a meal, your body breaks down nutrients to extract energy. NAD⁺ captures the electrons released, then transfers them to the mitochondria, enabling the production of ATP, essential for moving, thinking and recovering after exercise.
RAPID AND PROLONGED ACTION OF NAD⁺
NADH is the reduced form of NAD⁺, which means it is already charged with electrons and can be immediately oxidised to regenerate NAD⁺.
This process takes place in the mitochondrial electron transport chain, where NADH gives up its electrons to the enzyme complexes, triggering the production of ATP.
This reaction is instantaneous, resulting in an immediate increase in cellular energy.
Long-lasting action thanks to NR and Vitamin B3
Unlike NADH, which is directly available, Nicotinamide Riboside (NR) acts as a precursor to NAD⁺. Once absorbed, it is gradually converted to Nicotinamide Mononucleotide (NMN) via the action of the enzyme Nicotinamide Riboside Kinase (NRK). NMN is then converted to NAD⁺ by NMN adenylyltransferase (NMNAT).
This process takes longer, but enables a continuous and sustained release of NAD⁺, guaranteeing a prolonged supply of cellular energy and improved metabolic regeneration over several hours.
Vitamin B3 (Nicotinamide or Niacin) also plays a key role, as it is essential for the proper functioning of the enzymes involved in the synthesis and recycling of NAD⁺. It helps maintain a constant rate of NAD⁺ production and prevents deficiencies that could slow down metabolic efficiency.
Example: Imagine a sprinter at the starting line. As soon as the gun goes off, he instantly draws on his reserves of fast energy to explode out of the blocks, which represents the immediate action of NADH.
But to maintain its effort over time, it needs a regular supply of energy, comparable to NR, which gradually releases NAD⁺.
Finally, to avoid a slump in performance and optimise your metabolic endurance, Vitamin B3 helps to stabilise energy production and regulate the enzymatic processes that sustain the effort right up to the finish line.
WHY IS THIS SYNERGY IDEAL?
The combination of NADH for immediate action, NR for sustained release and vitamin B3 to support enzymatic conversion results in a stable, long-lasting energy effect. This avoids sudden fluctuations in NAD⁺ levels and ensures optimal cell function over the short and long term.
This combination is ideal for those looking for a quick energy boost while supporting their metabolism over time, whether for physical activity, cognitive performance or cellular recovery.
WHY INCREASE YOUR NAD+ LEVEL?
After the age of 30, NAD⁺ levels decline further, leading to mitochondrial decline, reduced insulin sensitivity and increased oxidative stress, promoting metabolic and neurodegenerative diseases. Restoring NAD⁺ may improve cellular energy production, optimise metabolism and could slow certain effects of ageing.
THREE WAYS TO OPTIMISE OUR NAD+ SYSTEM
Three ways to optimise our NAD⁺
NR, NADH and Vitamin B3 use distinct metabolic pathways to increase NAD⁺ levels, ensuring a rapid rise, but also a medium- and long-term increase.
1. Nicotinamide Riboside (NR) - The salvage pathway
NR is a direct precursor of NAD⁺ which follows the salvage pathway. It is phosphorylated by Nicotinamide Riboside Kinase (NRK) to Nicotinamide Mononucleotide (NMN), then converted to NAD⁺ by the enzyme NMN adenylyltransferase (NMNAT). This pathway is rapid and efficient, as it bypasses certain limiting steps in nicotinamide metabolism.
2. NADH - Redox cycle and indirect impact on NAD⁺
NADH is the reduced form of NAD⁺, involved in energy production via the electron transport chain in mitochondria. Once absorbed, it is largely oxidised to NAD⁺ before entering the circulation. Inside cells, the NAD⁺/NADH balance is finely regulated by glycolysis, the Krebs cycle and oxidative phosphorylation. NADH provides an immediate energy boost by stimulating ATP production, but does not sustainably increase the NAD⁺ pool.
3. Nicotinamide (Niacinamide) - The "Preiss-Handler" and "salvage pathway
Nicotinamide (Niacinamide) mainly follows the NAD⁺ recovery pathway. It is converted to Nicotinamide Mononucleotide (NMN) via the action of Nicotinamide Phosphoribosyltransferase (NAMPT), then converted to NAD⁺ by NMNAT. Once consumed, NAD⁺ can be degraded to Nicotinamide and reused in this same pathway. Less costly and more stable than NR, its effectiveness nevertheless depends on the activity of NAMPT, which can be limited by ageing and certain cellular stresses.
GASTRO-RESISTANT CAPSULES DRCAPS
We have chosen DRCAPS gastro-resistant capsules to protect NADH from stomach acid and ensure optimum absorption of active ingredients such as NR. Thanks to this technology, release is delayed until the small intestine, where absorption is most effective. The result: greater bioavailability and fewer wasted molecules. Because let's face it, swallowing a supplement so that it's destroyed before it's useful is a bit like paying for a gym membership... and never going.
WHY IS IT IMPORTANT TO MAINTAIN A GOOD NADH/NAD+ RATIO?
A poor ratio NADH/NAD⁺It's like cooking with too little oxygen in a fire: instead of a beautiful flame that heats up efficiently, it smokes and suffocates you.
The result? Reduced energy production, leading to fatigue and poor performance. It accelerates ageing by limiting cell repair and increases the risk of neurodegenerative diseases. Excess NADH promotes oxidative stress, disrupting metabolism and insulin sensitivity. This can lead to metabolic disorders, chronic inflammation and neuronal degeneration.
WHAT ARE THE BENEFITS FOR SPORTSPEOPLE?
More and more sportspeople are incorporating NAD⁺ precursors into their routine, because by boosting mitochondrial function and ATP production, they gain significant energy and endurance.
Some studies show that NAD+ precursor supplementation can increase aerobic capacity performance by up to 30 % in trained athletes, which is much better than the results of beta-alanine supplementation.
LACK OF NAD⁺ = A BARRIER TO WEIGHT LOSS
Obesity disrupts the functioning of the mitochondria, the little energy centres of our cells, by reducing the enzymatic activity needed to produce energy. The result? A more rigid metabolism, less able to adapt to dietary variations, and an increased risk of type 2 diabetes and cardiovascular disease.
Adipose tissue plays a key role in metabolic balance, notably through the biosynthesis of NAD⁺, a cofactor essential for energy production. This production depends on an enzyme called NAMPT, levels of which are greatly reduced in obese people. Less NAMPT means less NAD⁺, which impairs energy regulation and promotes the uncontrolled enlargement of fat cells.
Preclinical studies show that eNAMPT (the extracellular form of NAMPT) could help restore NAD⁺ by supplying NMN to the hypothalamus, a key area of the brain for metabolic regulation. In mice, the eNAMPT contained in certain extracellular vesicles has even been associated with a slowdown in ageing and greater longevity.
On the other hand, a deficiency of NAMPT in adipose tissue can lead to fibrosis of the fatty tissue, a loss of its plasticity and a reduction in the mitochondria's capacity to produce energy. In other words, without the right balance of NAD⁺, adipose tissue goes from being an essential metabolic regulator... to an aggravating factor in metabolic disorders.
LOSE WEIGHT WITH NAD+?
This meta-analysis of 18 randomised controlled trials examined the effect of NAD⁺ precursors (nicotinic acid and nicotinamide) on weight, BMI and obesity-related hormones. The study involved 5,144 adults, with and without metabolic conditions, receiving doses of 250 to 3,000 mg/day over 4 to 144 weeks. The results showed a minimal reduction in BMI (-0.19) and an increase in adiponectin levels, but only with nicotinic acid.
WHAT IS THE DIFFERENCE BETWEEN NAD+ AND NADH?
NAD⁺ is the oxidised form of NAD, and its main role is to act as an electron acceptor, facilitating essential metabolic reactions. It is involved in several key processes:
- Glycolysis: The conversion of glucose into energy, as a first charge of fuel.
- The Krebs cycle: A process in the mitochondria that maximises energy production.
- The electron transport chain : The final stage where ATP (cellular energy) is produced.
- DNA repair and sirtuin activation: mechanisms that influence longevity and resistance to oxidative stress.
Example: Imagine you've just eaten a good meal. Your body will break down this food into nutrients, but without NAD⁺, this energy could not be extracted and used. It's what allows the cells to convert what you eat into ATP, in other words, the fuel that keeps you fit and active every day!
NADH (Hydrogenated Nicotinamide Adenine Dinucleotide) :
is the reduced form of NAD⁺. It plays an essential role in energy metabolism by transporting electrons to the electron transport chain located in the mitochondria. This process is essential for the production of ATP, the main source of energy used by the body to carry out its vital functions.
If NAD⁺ acts as a scavenger of electrons, NADH is the transporter that brings them to where they will be used to generate energy. Once it arrives in the electron transport chain, NADH gives up its electrons, enabling the production of ATP and thus fuelling all cellular activities, from muscle contractions to tissue regeneration.
WHY NOT SUPPLEMENT DIRECTLY WITH NAD+?
NAD supplementation is degraded in the small intestine by intestinal epithelial cells. It is then converted into NMN by several intestinal enzymes. However, if you take NAD+ precursors as in our formula, the body will convert it into NAD+ without any significant degradation. This is why it is much more effective to supplement with NAD+ precursors to increase your NAD levels.
WHO ARE THE PRECURSORS OF NAD+?
- Nicotinamide Riboside (NR): The most direct precursor
- Nicotinamide Mononucleotide (NMN): Intermediate stage of NAD⁺
- Nicotinamide (Niacinamide) : The classic recovery route
- Nicotinic acid (Niacin) : The Preiss-Handler pathway
- Tryptophan: The most complex pathway
- NADH (Hydrogenated Nicotinamide Adenine Dinucleotide); Indirect precursor of NAD+.
HOW TO INCREASE NAD+ LEVELS NATURALLY?
Adopt a suitable diet: eat foods rich in niacin (vitamin B3) such as fish, poultry, eggs, green vegetables and seeds.
Exercise regularly: Endurance training and strength training promote an active metabolism and naturally increase NAD⁺.
Protect your cells against inflammation: Avoid ultra-processed foods, smoking and chronic stress. Avoid alcohol and adopt a balanced diet and an active lifestyle.
Optimise your sleep: a regular circadian rhythm favours the activation of sirtuins, essential enzymes that depend on NAD⁺ to maintain cell balance.
WHERE TO BUY NMN?
NMN (Nicotinamide Mononucleotide) is no longer authorised for sale in Europe, mainly because of its uncertain regulatory status as a Novel Food. However, its alternative, NR (Nicotinamide Riboside), remains authorised and available on the European market.
Scientific studies have compared these two NAD⁺ precursors and shown that they are both capable of effectively increasing NAD⁺ levels in the body. Although their uptake pathways differ slightly, their impact on energy metabolism and cellular longevity is equivalent, making NR an excellent alternative to NMN for supporting cellular functions and slowing down ageing.
Opinion
Since I started using this product, I've noticed a slight increase in my energy levels. The capsules are easy to take. I recommend it without hesitation!
Since I started taking this product, I've noticed a slight improvement in my energy levels. The capsules are easy to take. I recommend it without hesitation!
I've been using these DIX brand NAD+ capsules for several weeks now in the hope of improving my vitality, mental clarity and memory, which are beginning to decline as I get older. This supplement, made in France, guarantees a certain quality and compliance with standards. Its formula, which includes NR, NADH and vitamin B3, is contained in a vegetarian capsule that can be digested ... (voir plus)
Let me explain. At the age of 43, I have a balanced genetic translocation between 5 and 11, which makes no difference to my everyday life. However, the day I decided to become a father was a challenge. I started taking this vitamin supplement after noticing a significant drop in my energy levels, experiencing chronic fatigue that made me feel very tired. (voir plus)
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